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Article

STI571 (Glivec) suppresses the expression of vascular endothelial growth factor in the gastrointestinal stromal tumor cell line, GIST-T1.

World journal of gastroenterology - 7 Feb 2006

Jin Toufeng, Nakatani Hajime, Taguchi Takahiro, Nakano Takumi, Okabayashi Takehiro, Sugimoto Takeki, Kobayashi Michiya, Araki Keijiro

Abstract excerpt

AIM: To estimate whether STI571 inhibits the expression of vascular endothelial growth factor (VEGF) in the gastrointestinal stromal tumor (GIST) cells. METHODS: We used GIST cell line, GIST-T1. It has a heterogenic 57-bp deletion in exon 11 to produce a mutated c-KIT, which results in constitutive activation of c-KIT. Cells were treated with/without STI571 or stem cell factor (SCF). Transcription and expression...

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Identifiers

PMID: 16521182
DOI: 10.3748/wjg.v12.i5.703
PMCID: PMC4066119

Genes

KIT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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