Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease?

Nature cell biology - 1 Jul 2000

Goldberg M S, Lansbury P T

Abstract excerpt

The first gene to be linked to Parkinson's disease encodes the neuronal protein alpha-synuclein. Recent mouse and Drosophila models of Parkinson's disease support a central role for the process of alpha-synuclein fibrillization in pathogenesis. However, some evidence indicates that the fibril itself may not be the pathogenic species. Our own biophysical studies suggest that a structured fibrillization...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ubiquitin Thiolesterase
Share to alpha-Synuclein
Share to Huntington Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ligases

Share to Parkinson Disease

Share to Synucleins

Share to Thiolester Hydrolases

Share to Ubiquitin-Protein Ligases

Source

Identifiers

PMID: 10878819
DOI: 10.1038/35017124

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease?PMID 10878819Read ↗

Advances in understanding the function of alpha-synuclein: implications for Parkinson’s diseaseSemantic proximity Read ↗

Defining α-synuclein species responsible for Parkinson’s disease phenotypes in miceSemantic proximity Read ↗

Pre‐fibrillar α‐synuclein variants with impaired β‐structure increase neurotoxicity in Parkinson's disease modelsSemantic proximity Read ↗

Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease.Semantic proximity Read ↗

Fibrillization of alpha-synuclein and tau in familial Parkinson's disease caused by the A53T alpha-synuclein mutation.Semantic proximity Read ↗

Aggregation-defective alpha-synuclein mutants inhibit the fibrillation of Parkinson's disease-linked alpha-synuclein variants.Semantic proximity Read ↗

What’s to like about the prion-like hypothesis for the spreading of aggregated α-synuclein in Parkinson disease?Semantic proximity Read ↗

The α‐Synucleinopathies: Parkinson's Disease, Dementia with Lewy Bodies, and Multiple System AtrophySemantic proximity Read ↗

Parkinsons Disease and other α-SynucleinopathiesSemantic proximity Read ↗

Molecular pathogenesis of movement disorders: are protein aggregates a common link in neuronal degeneration?Semantic proximity Read ↗

Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies.Semantic proximity Read ↗

Molecular mechanisms of alpha-synuclein neurodegeneration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.