Article
Expression of the Stp1 LMW-PTP and inhibition of protein CK2 display a cooperative effect on immunophilin Fpr3 tyrosine phosphorylation and Saccharomyces cerevisiae growth.
Cellular and molecular life sciences : CMLS - 1 May 2004
Marchetta M, Gamberi T, Sarno S, Magherini F, Raugei G, Camici G, Pinna L A, Modesti A
Abstract excerpt
Although the yeast genome does not encode bona fide protein tyrosine kinases, tyrosine-phosphorylated proteins are numerous, suggesting that besides dual-specificity kinases, some Ser/Thr kinases are also committed to tyrosine phosphorylation in Saccharomyces cerevisiae. Here we show that blockage of the highly pleiotropic Ser/Thr kinase CK2 with a specific inhibitor synergizes with the overexpression of Stp1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.