Article
In Saccharomyces cerevisiae an unbalanced level of tyrosine phosphorylation down-regulates the Ras/PKA pathway.
The international journal of biochemistry & cell biology - 1 Mar 2006
Magherini Francesca, Busti Stefano, Gamberi Tania, Sacco Elena, Raugei Giovanni, Manao Gianpaolo, Ramponi Giampietro, Modesti Alessandra, Vanoni Marco
Abstract excerpt
The role of tyrosyl phosphorylation/dephosphorylation in the budding yeast Saccharomyces cerevisiae, whose genome does not encode typical tyrosine kinases, has long remained elusive. Nevertheless, several protein kinases phosphorylating poly(TyrGlu) substrates have been identified. In this work, we use the expression of the low molecular weight tyrosine phosphatase Stp1 from the distantly related yeast...
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