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Effects of the DRD3 Ser9Gly polymorphism on aripiprazole efficacy in schizophrenic patients as modified by clinical factors.

Progress in neuro-psychopharmacology & biological psychiatry - 30 Apr 2009

Chen Shih-Fen, Shen Yu-Chih, Chen Chia-Hsiang

Abstract excerpt

Aripiprazole, a novel antipsychotic agent, has a unique pharmacological action (partial agonist) on the dopamine neurotransmission system. Aripiprazole has high affinity for dopamine D2 and D3 receptors (DRD2 and DRD3). We investigated whether the efficacy of aripiprazole can be predicted by a functional DRD3 gene polymorphism Ser9Gly (rs6280) as modified by clinical factors in Han Chinese hospitalized patients...

Topics

Adult
Analysis of Variance
Antipsychotic Agents
Aripiprazole
Female
Genotype
Glycine
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Pharmacogenetics

Piperazines

Polymorphism, Restriction Fragment Length

Psychiatric Status Rating Scales

Quinolones

Receptors, Dopamine D3

Retrospective Studies

Schizophrenia

Source

Identifiers

PMID: 19302829
DOI: 10.1016/j.pnpbp.2009.01.007

Genes

DRD3
DRD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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