Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activity (transcription) of the genes for MLH1, MSH2 and p53 in sporadic colorectal tumours with micro-satellite instability.

British journal of cancer - 17 May 2004

Tou S I H, Drye E R, Boulos P B, Hollingsworth S J

Abstract excerpt

Micro-satellite instability (MSI) is relevant in the management of colorectal cancers (CRC) and relies on analysis of gene mutations, or production of the proteins involved in DNA mismatch repair (e.g. MLH1, MSH2). p53 mutation is also relevant in MSI, but high-level CRC (MSI-H) demonstrate fewer mutations than low-level (MSI-L) or stable (MSS) cancers. Recently, the importance of gene activity (transcription) in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to DNA Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, p53

Share to MutL Protein Homolog 1

Share to MutS Homolog 2 Protein

Share to Neoplasm Proteins

Share to Proto-Oncogene Proteins

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 15138486
DOI: 10.1038/sj.bjc.6601823
PMCID: PMC2409469

Genes

MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activity (transcription) of the genes for MLH1, MSH2 and p53 in sporadic colorectal tumours with micro-satellite instability.PMID 15138486Read ↗

Genetic and epigenetic modification of MLH1 accounts for a major share of microsatellite-unstable colorectal cancers.Semantic proximity Read ↗

MLH1 Promoter Methylation and Gene Silencing is the Primary Cause of Microsatellite Instability in Sporadic Endometrial CancersSemantic proximity Read ↗

Differential involvement of the hypermethylator phenotype in hereditary and sporadic colorectal cancers with high-frequency microsatellite instability.Semantic proximity Read ↗

The role of MLH1, MSH2 and MSH6 in the development of multiple colorectal cancersSemantic proximity Read ↗

Immunohistochemical Pattern of MLH1/MSH2 Expression Is Related to Clinical and Pathological Features in Colorectal Adenocarcinomas with Microsatellite InstabilitySemantic proximity Read ↗

Analysis of candidate target genes for mononucleotide repeat mutation in microsatellite instability-high (MSI-H) endometrial cancer.Semantic proximity Read ↗

Microsatellite instability and the clinicopathological features of sporadic colorectal cancer.Semantic proximity Read ↗

Evaluation of microsatellite instability, hMLH1 expression and hMLH1 promoter hypermethylation in defining the MSI phenotype of colorectal cancer.Semantic proximity Read ↗

Distinction of Hereditary Nonpolyposis Colorectal Cancer and Sporadic Microsatellite-Unstable Colorectal Cancer through Quantification of MLH1 Methylation by Real-time PCRSemantic proximity Read ↗

Distinct clinicopathologic and genetic profiles in sporadic gastric cancer with different mutator phenotypes.Semantic proximity Read ↗

MSH3 protein expression and nodal status in MLH1-deficient colorectal cancers.Semantic proximity Read ↗

MTHFR C677T has differential influence on risk of MSI and MSS colorectal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.