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Article

Biochemical characterization of Leishmania major aquaglyceroporin LmAQP1: possible role in volume regulation and osmotaxis.

Molecular microbiology - 1 Aug 2007

Figarella Katherine, Uzcategui Nestor L, Zhou Yao, LeFurgey Ann, Ouellette Marc, Bhattacharjee Hiranmoy, Mukhopadhyay Rita

Abstract excerpt

The Leishmania major aquaglyceroporin, LmAQP1, is responsible for the transport of trivalent metalloids, arsenite and antimonite. We have earlier shown that downregulation of LmAQP1 provides resistance to trivalent antimony compounds whereas increased expression of LmAQP1 in drug-resistant parasites can reverse the resistance. In this paper we describe the biochemical characterization of LmAQP1. Expression of...

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PMID: 17640270
DOI: 10.1111/j.1365-2958.2007.05845.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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