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Article

Alteration in glycerol and metalloid permeability by a single mutation in the extracellular C-loop of Leishmania major aquaglyceroporin LmAQP1.

Molecular microbiology - 1 Dec 2008

Uzcategui Nestor L, Zhou Yao, Figarella Katherine, Ye Jun, Mukhopadhyay Rita, Bhattacharjee Hiranmoy

Abstract excerpt

The Leishmania major aquaglyceroporin, LmAQP1, is responsible for the transport of antimonite [Sb(III)], an activated form of Pentostam or Glucantime. Downregulation of LmAQP1 provides resistance to trivalent antimony compounds and increased expression of LmAQP1 in drug-resistant parasites can re...

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Identifiers

PMID: 19019150
DOI: 10.1111/j.1365-2958.2008.06494.x
PMCID: PMC2702841

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19019150-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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