Article
Association of polymorphisms of PTGS2 and CYP8A1 with myocardial infarction.
Clinical chemistry and laboratory medicine - 1 Jan 2009
Xie Xiang, Ma Yi-tong, Fu Zhen-yan, Yang Yi-ning, Ma Xiang, Chen Bang-dang, Wang Ying-hong, Liu Fen
Abstract excerpt
BACKGROUND: Cyclooxygenase-2 (COX-2) and prostacyclin synthase (PGIS) are enzymes involved in prostaglandin and prostacyclin synthesis, which have been linked to cardiovascular disease risk. We hypothesized that genetic variations altering the function of these enzymes would modify the risk of myocardial infarction (MI). METHODS: In a Chinese case control study of MI patients (n=356) and healthy controls (n=350),...
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