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Article

Calcium and a calcium-dependent protein kinase regulate gamete formation and mosquito transmission in a malaria parasite.

Cell - 14 May 2004

Billker Oliver, Dechamps Sandrine, Tewari Rita, Wenig Gerald, Franke-Fayard Blandine, Brinkmann Volker

Abstract excerpt

Transmission of malaria parasites to mosquitoes is initiated by the obligatory sexual reproduction of the parasite within the mosquito bloodmeal. Differentiation of specialized transmission stages, the gametocytes, into male and female gametes is induced by a small mosquito molecule, xanthurenic acid (XA). Using a Plasmodium berghei strain expressing a bioluminescent calcium sensor, we show that XA triggers a...

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PMID: 15137943
DOI: 10.1016/s0092-8674(04)00449-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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