Article
Interval estimation of genetic susceptibility for retrospective case-control studies.
BMC genetics - 11 May 2004
Zaykin Dmitri V, Meng Zhaoling, Ghosh Sujit K
Abstract excerpt
BACKGROUND: This article describes classical and Bayesian interval estimation of genetic susceptibility based on random samples with pre-specified numbers of unrelated cases and controls. RESULTS: Frequencies of genotypes in cases and controls can be estimated directly from retrospective case-control data. On the other hand, genetic susceptibility defined as the expected proportion of cases among individuals with...
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