Article
The monocyte Fcgamma receptors FcgammaRI/gamma and FcgammaRIIA differ in their interaction with Syk and with Src-related tyrosine kinases.
Journal of leukocyte biology - 1 Aug 2004
Huang Zhen-Yu, Hunter Sharon, Kim Moo-Kyung, Chien Paul, Worth Randall G, Indik Zena K, Schreiber Alan D
Abstract excerpt
There are important differences in signaling between the Fc receptor for immunoglobulin G (IgG) FcgammaRIIA, which uses the Ig tyrosine-activating motif (ITAM) within its own cytoplasmic domain, and FcgammaRI, which transmits signals by means of an ITAM located within the cytoplasmic domain of its associated gamma-chain. For example, in transfected epithelial cells and COS-1 cells, FcgammaRIIA mediates...
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