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DNA damage in lung after oral exposure to diesel exhaust particles in Big Blue rats.

Mutation research - 4 Jun 2004

Müller Anne K, Farombi E Olatunde, Møller Peter, Autrup Herman N, Vogel Ulla, Wallin Håkan, Dragsted Lars O, Loft Steffen, Binderup Mona-Lise

Abstract excerpt

Several chemical mutagens and carcinogens, including polycyclic aromatic hydrocarbons (PAHs) and nitrated PAHs, are adsorbed to the surface of diesel exhaust particles (DEP). DEP can induce formation of reactive oxygen species and cause oxidative DNA damage as well as bulky carcinogen DNA adducts. Lung tissue is a target organ for DEP induced cancer following inhalation. Recent studies have provided evidence that...

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Identifiers

PMID: 15135646
DOI: 10.1016/j.mrfmmm.2004.02.010

Genes

ERCC1
OGG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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