FAPalpha, a surface peptidase expressed during wound healing, is a tumor suppressor.

doi:10.1038/sj.onc.1207730

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Article

FAPalpha, a surface peptidase expressed during wound healing, is a tumor suppressor.

Oncogene - 15 Jul 2004

Ramirez-Montagut Teresa, Blachere Nathalie E, Sviderskaya Elena V, Bennett Dorothy C, Rettig Wolfgang J, Garin-Chesa Pilar, Houghton Alan N

Abstract excerpt

Fibroblast activation protein-alpha (FAP) is a cell surface serine protease expressed at sites of tissue remodeling in embryonic development. FAP is not expressed by mature somatic tissues except activated melanocytes and fibroblasts in wound healing or tumor stroma. FAP expression is specifically silenced in proliferating melanocytic cells during malignant transformation. To study the role of FAP as a tumor...

Topics

Animals
Apoptosis
Cell Cycle
Contact Inhibition
Dipeptidyl Peptidase 4
Endopeptidases
Gelatinases
Melanocytes
Melanoma
Membrane Proteins
Mice
Mutation
Serine
Serine Endopeptidases
Transfection
Tumor Suppressor Proteins
Wound Healing

Source

Open in PubMed

Identifiers

PMID: 15133496
DOI: 10.1038/sj.onc.1207730

Genes

FAP
RAG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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