The Development of Primary and Secondary Lymphoid Tissues in the Nurse Shark <i>Ginglymostoma cirratum</i>: B‐Cell Zones Precede Dendritic Cell Immigration and T‐Cell Zone Formation During Ontogeny of the Spleen

Abstract excerpt

Secondary lymphoid tissue and immunoglobulin (Ig) production in mammals is not fully developed at birth, requiring time postnatally to attain all features required for adaptive immune responses. The immune system of newborn sharks - the oldest vertebrate group having adaptive immunity - also displays immature characteristics such as low serum IgM concentration and high levels of IgM1gj, an innate-like Ig. Primary...

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