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Article

Arsenic trioxide-induced death of neuroblastoma cells involves activation of Bax and does not require p53.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2004

Karlsson Jenny, Øra Ingrid, Pörn-Ares Isabella, Påhlman Sven

Abstract excerpt

PURPOSE: On the basis of clinical studies showing that arsenic trioxide (As(2)O(3)), via an apoptotic mechanism, and with minimal toxicity induces complete remission in patients with refractory acute promyelocytic leukemia and that multidrug-resistant and p53-mutated neuroblastoma cells are sensitive to As(2)O(3) both in vitro and in vivo, we searched for molecular mechanisms involved in the As(2)O(3)-induced...

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Identifiers

PMID: 15131059
DOI: 10.1158/1078-0432.ccr-03-0309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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