Article
Arsenic trioxide concentration determines the fate of Ewing's sarcoma family tumors and neuroblastoma cells in vitro.
FEBS letters - 4 Sept 2006
Jung Hyun Sook, Kim Han-Seong, Lee Min-Jae, Shin Hee Young, Ahn Hyo Seop, Ryu Kyung-Ha, Seoh Ju-Young, Kim Chong Jai, Jang Ja June
Abstract excerpt
Arsenic trioxide (As(2)O(3)) induces both the differentiation and apoptosis of acute promyelocytic leukemia cells in a concentration dependent manner. We assessed the effects of As(2)O(3) in CADO-ES Ewing's sarcoma (ES), JK-GMS peripheral primitive neuroectodermal tumor (PNET), and SH-SY5Y neuroblastoma cells, as they share common histogenetic backgrounds. As(2)O(3) at low concentrations (0.1-1 microM) induced...
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