Article
Mutations in exon 11 of the c-kit gene in a myogenic tumor and a neurogenic tumor as well as in gastrointestinal stromal tumors. Utility of c-kit mutation as a prognostic biomarker for gastrointestinal mesenchymal tumor.
Digestive surgery - 1 Jan 2003
Yasuoka Rie, Sakakura Chohei, Shimomura Katsumi, Fujita Yoshifumi, Nakanishi Masayoshi, Aragane Hideki, Hagiwara Akeo, Bamba Masamichi, Abe Tatsuo, Yamagishi Hisakazu
Abstract excerpt
BACKGROUND/AIMS: Gain-of-function mutations in exons 9, 11 and 13 of the c-kit gene in gastrointestinal stromal tumors (GISTs) have been identified, and it has been reported that the prognosis is worse for patients with mutation-positive GISTs than for those with mutation-negative GISTs. We studi...
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