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Article

Expression of fragments of translation initiation factor eIF4GI reveals a nuclear localisation signal within the N-terminal apoptotic cleavage fragment N-FAG.

Journal of cell science - 15 May 2004

Coldwell Mark J, Hashemzadeh-Bonehi Lida, Hinton Tracey M, Morley Simon J, Pain Virginia M

Abstract excerpt

The eukaryotic initiation factor eIF4GI plays a central role in the assembly of a competent initiation complex at the 5' end of an mRNA. Five isoforms of eIF4G exist in cells, arising from alternative translation initiation. During picornaviral infection or apoptosis, eIF4GI is cleaved proteolytically to yield distinct fragments. Using HeLa cells, we have examined the fate of these proteins in the cell. We have...

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PMID: 15128869
DOI: 10.1242/jcs.01106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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