Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Kinetic and mechanistic studies of a cell cycle protein phosphatase Cdc14.

The Journal of biological chemistry - 16 Jul 2004

Wang Wei-Qing, Bembenek Joshua, Gee Kyle R, Yu Hongtao, Charbonneau Harry, Zhang Zhong-Yin

Abstract excerpt

The Cdc14 family of protein phosphatases is conserved within eukaryotes and antagonizes the action of cyclin-dependent kinases, thereby promoting mitotic exit and cytokinesis. We performed a detailed kinetic and mechanistic study of the Cdc14 phosphatases with both small molecule aryl phosphates and a physiological protein substrate hCdh1. We found that Cdc14 displays a strong preference for two-ringed aryl...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aspartic Acid
Share to Aniline Compounds
Share to Catalysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrolysis

Share to Models, Chemical

Share to Organophosphorus Compounds

Share to Protein Tyrosine Phosphatases

Share to Spectrophotometry

Source

Identifiers

PMID: 15128740
DOI: 10.1074/jbc.M402217200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Kinetic and mechanistic studies of a cell cycle protein phosphatase Cdc14.PMID 15128740Read ↗

[Protein phosphatases that control cell cycle].Semantic proximity Read ↗

Reduced Cdc14 phosphatase activity impairs septation, hyphal differentiation and pathogenesis and causes echinocandin hypersensitivity in <i>Candida albicans</i>Semantic proximity Read ↗

Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription.Semantic proximity Read ↗

Method for identifying phosphorylated substrates of specific cyclin/cyclin-dependent kinase complexes.Semantic proximity Read ↗

Loss of a protein phosphatase 2A regulatory subunit (Cdc55p) elicits improper regulation of Swe1p degradation.Semantic proximity Read ↗

Structural and functional analysis of the phosphoryl transfer reaction mediated by the human small C-terminal domain phosphatase, Scp1.Semantic proximity Read ↗

Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells.Semantic proximity Read ↗

The energetic network of hotspot residues between Cdc25B phosphatase and its protein substrate.Semantic proximity Read ↗

Multi-site phosphorylation of Pho4 by the cyclin-CDK Pho80-Pho85 is semi-processive with site preference.Semantic proximity Read ↗

The structural basis for tight control of PP2A methylation and function by LCMT-1.Semantic proximity Read ↗

Probing Mechanistic Similarities between Response Regulator Signaling Proteins and Haloacid Dehalogenase Phosphatases.Semantic proximity Read ↗

The Dcr2p phosphatase destabilizes Sic1p in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.