Article
Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids.
Human molecular genetics - 1 Jul 2004
Tantisira Kelan G, Lake Stephen, Silverman Eric S, Palmer Lyle J, Lazarus Ross, Silverman Edwin K, Liggett Stephen B, Gelfand Erwin W, Rosenwasser Lanny J, Richter Brent, Israel Elliot, Wechsler Michael, Gabriel Stacey, Altshuler David, Lander Eric, Drazen Jeffrey, Weiss Scott T
Abstract excerpt
Corticosteroids mediate a variety of immunological actions and are commonly utilized in the treatment of a wide range of diseases. Unfortunately, therapy with this class of medications is associated with a large proportion of non-responders and significant side effects. Inhaled corticosteroids are the most commonly used asthma controller therapy. However, asthmatic response to corticosteroids also varies widely...
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