Article
Association of corticotropin-releasing hormone receptor-2 genetic variants with acute bronchodilator response in asthma.
Pharmacogenetics and genomics - 1 May 2008
Poon Audrey H, Tantisira Kelan G, Litonjua Augusto A, Lazarus Ross, Xu Jingsong, Lasky-Su Jessica, Lima John J, Irvin Charles G, Hanrahan John P, Lange Christoph, Weiss Scott T
Abstract excerpt
OBJECTIVE: Corticotropin-releasing hormone receptor (CRHR)-2 participates in smooth muscle relaxation response and may influence acute airway bronchodilator response to short-acting beta2-agonist treatment of asthma. We aim to assess associations between genetic variants of CRHR2 and acute bronchodilator response in asthma. METHODS: We investigated 28 single nucleotide polymorphisms in CRHR2 for associations with...
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