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Article

Chromosome 17: association of a large inversion polymorphism with corticosteroid response in asthma.

Pharmacogenetics and genomics - 1 Aug 2008

Tantisira Kelan G, Lazarus Ross, Litonjua Augusto A, Klanderman Barbara, Weiss Scott T

Abstract excerpt

A 900-kb inversion exists within a large region of conserved linkage disequilibrium (LD) on chromosome 17. CRHR1 is located within the inversion region and associated with inhaled corticosteroid response in asthma. We hypothesized that CRHR1 variants are in LD with the inversion, supporting a potential role for natural selection in the genetic response to corticosteroids. We genotyped six single nucleotide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18622266
DOI: 10.1097/FPC.0b013e3282fe6ebf
PMCID: PMC3225071

Genes

CRHR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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