Article
Intramolecular transmission of the ATP regulatory signal in Escherichia coli aspartate transcarbamylase: specific involvement of a clustered set of amino acid interactions at an interface between regulatory and catalytic subunits.
Journal of molecular biology - 10 Feb 1995
De Staercke C, Van Vliet F, Xi X G, Rani C S, Ladjimi M, Jacobs A, Triniolles F, Hervé G, Cunin R
Abstract excerpt
Aspartate transcarbamylase from Escherichia coli is stimulated by ATP and feedback-inhibited by CTP and UTP. Previous work allowed the identification of the hydrophobic interface between the two domains of the regulatory chain as a structural element specifically involved in the transmission of t...
Topics
- Adenosine Triphosphate
- Allosteric Regulation
- Amino Acids
- Aspartate Carbamoyltransferase
- Aspartic Acid
- Binding, Competitive
- Cytidine Triphosphate
- Escherichia coli
- Kinetics
- Mutation
- Protein Conformation
- Uridine Triphosphate