Conversion of the noncooperative Bacillus subtilis aspartate transcarbamoylase into a cooperative enzyme by a single amino acid substitution.

doi:10.1021/bi00123a017

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Article

Conversion of the noncooperative Bacillus subtilis aspartate transcarbamoylase into a cooperative enzyme by a single amino acid substitution.

Biochemistry - 3 Mar 1992

Stebbins J W, Kantrowitz E R

Abstract excerpt

Allosteric enzymes are part of a unique class of enzymes which regulate metabolic pathways. On the molecular level, allosteric regulation is the result of interactions between discrete binding sites on the enzyme. In order to accommodate these multiple binding sites, allosteric enzymes have evolv...

Topics

Alanine
Allosteric Regulation
Allosteric Site
Arginine
Aspartate Carbamoyltransferase
Bacillus subtilis
Biological Evolution
Kinetics
Mutagenesis, Site-Directed
Mutation

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