Importance of domain closure for homotropic cooperativity in Escherichia coli aspartate transcarbamylase.

doi:10.1021/bi00458a015

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Article

Importance of domain closure for homotropic cooperativity in Escherichia coli aspartate transcarbamylase.

Biochemistry - 13 Feb 1990

Newton C J, Kantrowitz E R

Abstract excerpt

The importance of the interdomain bridging interactions observed only in the R-state structure of Escherichia coli aspartate transcarbamylase between Glu-50 of the carbamoyl phosphate domain with both Arg-167 and Arg-234 of the aspartate domain has been investigated by using site-specific mutagen...

Topics

Adenosine Triphosphate
Alanine
Allosteric Regulation
Aspartate Carbamoyltransferase
Aspartic Acid
Cytidine Triphosphate
Enzyme Activation
Escherichia coli
Kinetics
Mutation
Phosphonoacetic Acid
Succinates

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