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Article

Importance of domain closure for homotropic cooperativity in Escherichia coli aspartate transcarbamylase.

Biochemistry - 13 Feb 1990

Newton C J, Kantrowitz E R

Abstract excerpt

The importance of the interdomain bridging interactions observed only in the R-state structure of Escherichia coli aspartate transcarbamylase between Glu-50 of the carbamoyl phosphate domain with both Arg-167 and Arg-234 of the aspartate domain has been investigated by using site-specific mutagenesis. Two mutant versions of aspartate transcarbamylase were constructed, one with alanine at position 50...

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Source

Identifiers

PMID: 2185840
DOI: 10.1021/bi00458a015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Importance of domain closure for homotropic cooperativity in Escherichia coli aspartate transcarbamylase.PMID 2185840Read ↗

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