Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Syndecan-1 ectodomain shedding is regulated by the small GTPase Rab5.

The Journal of biological chemistry - 19 Dec 2008

Hayashida Kazutaka, Stahl Philip D, Park Pyong Woo

Abstract excerpt

The ectodomain shedding of syndecan-1, a major cell surface heparan sulfate proteoglycan, modulates molecular and cellular processes central to the pathogenesis of inflammatory diseases. Syndecan-1 shedding is a highly regulated process in which outside-in signaling accelerates the proteolytic cleavage of syndecan-1 ectodomains at the cell surface. Several extracellular agonists that induce syndecan-1 shedding...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to Collagenases
Share to Inflammation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphorylation

Share to Protein Structure, Tertiary

Share to Protein Transport

Share to rab5 GTP-Binding Proteins

Share to Syndecan-1

Source

Open in PubMed Open full text

Identifiers

PMID: 18957427
DOI: 10.1074/jbc.M804172200
PMCID: PMC2602919

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Syndecan-1 ectodomain shedding is regulated by the small GTPase Rab5.PMID 18957427Read ↗

Soluble syndecans: biomarkers for diseases and therapeutic optionsSemantic proximity Read ↗

Biological Functions of the Small Leucine-rich Proteoglycans: From Genetics to Signal TransductionSemantic proximity Read ↗

Rab GTPases implicated in inherited and acquired disorders.Semantic proximity Read ↗

A specific subset of RabGTPases controls cell surface exposure of MT1-MMP, extracellular matrix degradation and 3D invasion of macrophagesSemantic proximity Read ↗

Control of transforming growth factor β signal transduction by small GTPasesSemantic proximity Read ↗

RABGTPases in MT1-MMP trafficking and cell invasion: Physiology versus pathologySemantic proximity Read ↗

Ectodomain shedding of SHPS-1 and its role in regulation of cell migration.Semantic proximity Read ↗

A dual signaling cascade that regulates the ectodomain shedding of heparin-binding epidermal growth factor-like growth factor.Semantic proximity Read ↗

Understanding cadherin EGF LAG seven‐pass G‐type receptorsSemantic proximity Read ↗

Emerging roles for ectodomain shedding in the regulation of inflammatory responsesSemantic proximity Read ↗

Regulation of G-protein-coupled receptor activity by rab GTPases.Semantic proximity Read ↗

Constitutive Endocytosis of VEGFR2 Protects the Receptor against SheddingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.