Article
A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus.
The Journal of biological chemistry - 25 Jun 2004
Bohren Kurt M, Nadkarni Varsha, Song Jian H, Gabbay Kenneth H, Owerbach David
Abstract excerpt
Three SUMO (small ubiquitin-related modifier) genes have been identified in humans, which tag proteins to modulate subcellular localization and/or enhance protein stability and activity. We report the identification of a novel intronless SUMO gene, SUMO-4, that encodes a 95-amino acid protein having an 86% amino acid homology with SUMO-2. In contrast to SUMO-2, which is highly expressed in all of the tissues...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.