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Article

SUMO4 M55V variant is associated with diabetic nephropathy in type 2 diabetes.

Diabetes - 1 Apr 2007

Lin Hsing-Yi, Wang Chiao-Ling, Hsiao Pi-Jung, Lu Yung-Chuan, Chen Su-Yu, Lin Kun-Der, Hsin Shih-Chie, Hsieh Ming-Chia, Shin Shyi-Jang

Abstract excerpt

OBJECTIVE-SUMO4 mRNA was recently found to be mainly expressed in the kidney, and the methionine-to-valine substitution at codon 55 (M55V) variant of SUMO4 may induce higher nuclear factor-kappaB (NF-kappaB) activity. Because NF-kappaB is known to mediate the development of diabetic nephropathy, we examined the association between the SUMO4 M55V variant and the severity of diabetic nephropathy. RESEARCH DESIGN...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17229939
DOI: 10.2337/db06-1283

Genes

SUMO4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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SUMO4 M55V variant is associated with diabetic nephropathy in type 2 diabetes.PMID 17229939Read ↗

SUMO4 163 G>A variation is associated with kidney disease in Indian subjects with type 2 diabetes.Semantic proximity Read ↗

A M55V polymorphism in the SUMO4 gene is associated with a reduced prevalence of diabetic retinopathy in patients with Type 1 diabetes.Semantic proximity Read ↗

Small ubiquitin-like modifier-4 Met55Val polymorphism is associated with glycemic control of Type 2 diabetes mellitus in Taiwan.Semantic proximity Read ↗

No association of the SUMO4 polymorphism M55V variant in type 2 diabetes in Iranian subjects.Semantic proximity Read ↗

Association of SUMO4 M55V and -94ins/del gene variants with type-2 diabetes.Semantic proximity Read ↗

Polymorphism M55V in gene encoding small ubiquitin-like modifier 4 (SUMO4) protein associates with susceptibility to type 1 (and type 2) diabetes.Semantic proximity Read ↗

Association between the SUMO4 M55V Polymorphism and Susceptibility to Type 2 Diabetes Mellitus: A Meta-analysis.Semantic proximity Read ↗

Association of small ubiquitin-like modifier 4 (SUMO4) variant, located in IDDM5 locus, with type 2 diabetes in the Japanese population.Semantic proximity Read ↗

A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus.Semantic proximity Read ↗

Association of SUMO4, as a candidate gene for IDDM5, with susceptibility to type 1 diabetes in Asian populations.Semantic proximity Read ↗

Genetic heterogeneity in association of the SUMO4 M55V variant with susceptibility to type 1 diabetes.Semantic proximity Read ↗

Association of SUMO4 M55V polymorphism with type 1 diabetes in Chinese children.Semantic proximity Read ↗

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