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Article

SUMO4 163 G>A variation is associated with kidney disease in Indian subjects with type 2 diabetes.

Molecular biology reports - 1 May 2016

Sinha Nisha, Yadav Ashok Kumar, Kumar Vinod, Dutta Pinaki, Bhansali Anil, Jha Vivekanand

Abstract excerpt

Genetic susceptibility probably plays a role in the development and/or progression of diabetic kidney disease. Small ubiquitin-related modifier 4 (SUMO4) mRNA is expressed in human kidney. Substitution of methionine with valine at codon 55 (M55V) of SUMO4 gene induces higher nuclear factor-kB activity, which is known to mediate the development of kidney disease in individuals with diabetes. We investigated the...

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Share to Polymorphism, Single Nucleotide
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Predisposition to Disease

Share to Small Ubiquitin-Related Modifier Proteins

Source

Identifiers

PMID: 27055882
DOI: 10.1007/s11033-016-3979-x

Genes

SUMO4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SUMO4 163 G>A variation is associated with kidney disease in Indian subjects with type 2 diabetes.PMID 27055882Read ↗

SUMO4 M55V variant is associated with diabetic nephropathy in type 2 diabetes.Semantic proximity Read ↗

Small ubiquitin-like modifier-4 Met55Val polymorphism is associated with glycemic control of Type 2 diabetes mellitus in Taiwan.Semantic proximity Read ↗

Polymorphism M55V in gene encoding small ubiquitin-like modifier 4 (SUMO4) protein associates with susceptibility to type 1 (and type 2) diabetes.Semantic proximity Read ↗

No association of the SUMO4 polymorphism M55V variant in type 2 diabetes in Iranian subjects.Semantic proximity Read ↗

A M55V polymorphism in the SUMO4 gene is associated with a reduced prevalence of diabetic retinopathy in patients with Type 1 diabetes.Semantic proximity Read ↗

Association of SUMO4 M55V and -94ins/del gene variants with type-2 diabetes.Semantic proximity Read ↗

Association of SUMO4 M55V polymorphism with type 1 diabetes in Chinese children.Semantic proximity Read ↗

Association of small ubiquitin-like modifier 4 (SUMO4) variant, located in IDDM5 locus, with type 2 diabetes in the Japanese population.Semantic proximity Read ↗

Evidence for the role of small ubiquitin-like modifier 4 as a general autoimmunity locus in the Japanese population.Semantic proximity Read ↗

Association of SUMO4 Met55Val variation with increased insulin resistance in newly diagnosed type 2 diabetes in a Chinese population.Semantic proximity Read ↗

The single nucleotide polymorphism rs11643718 in SLC12A3 is associated with the development of diabetic kidney disease in Chinese people with type 2 diabetes.Semantic proximity Read ↗

SUMO4 Met55Val polymorphism is associated with coronary heart disease in Japanese type 2 diabetes individuals.Semantic proximity Read ↗

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