Article
Genotyping over 100,000 SNPs on a pair of oligonucleotide arrays.
Nature methods - 1 Nov 2004
Matsuzaki Hajime, Dong Shoulian, Loi Halina, Di Xiaojun, Liu Guoying, Hubbell Earl, Law Jane, Berntsen Tam, Chadha Monica, Hui Henry, Yang Geoffrey, Kennedy Giulia C, Webster Teresa A, Cawley Simon, Walsh P Sean, Jones Keith W, Fodor Stephen P A, Mei Rui
Abstract excerpt
We present a genotyping method for simultaneously scoring 116,204 SNPs using oligonucleotide arrays. At call rates >99%, reproducibility is >99.97% and accuracy, as measured by inheritance in trios and concordance with the HapMap Project, is >99.7%. Average intermarker distance is 23.6 kb, and 92% of the genome is within 100 kb of a SNP marker. Average heterozygosity is 0.30, with 105,511 SNPs having minor allele...
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