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Article

Generation of new landomycins by combinatorial biosynthetic manipulation of the LndGT4 gene of the landomycin E cluster in S. globisporus.

Chemistry & biology - 1 Apr 2004

Ostash Bohdan, Rix Uwe, Rix Lily L Remsing, Liu Tao, Lombo Felipe, Luzhetskyy Andriy, Gromyko Oleksandr, Wang Chenchen, Braña Alfredo F, Méndez Carmen, Salas José A, Fedorenko Victor, Rohr Jürgen

Abstract excerpt

A 3 kb DNA fragment from the Streptomyces globisporus 1912 landomycin E (LaE) biosynthetic gene cluster (lnd) was completely sequenced. Three open reading frames were identified, lndGT4, lndZ4, and lndZ5, whose probable translation products resemble a glycosyltransferase, a reductase, and a hydroxylase, respectively. Studies of generated mutants from disruption and complementation experiments involving the lndGT4...

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PMID: 15123249
DOI: 10.1016/j.chembiol.2004.03.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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