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Article

Iteratively acting glycosyltransferases involved in the hexasaccharide biosynthesis of landomycin A.

Chemistry & biology - 1 Jul 2005

Luzhetskyy Andriy, Fedoryshyn Marta, Dürr Clemens, Taguchi Takaaki, Novikov Volodymyr, Bechthold Andreas

Abstract excerpt

Detailed studies on the biosynthesis of the hexasaccharide side chain of landomycin A, produced by S. cyanogenus S136, revealed the function of each glycosyltransferase gene of the biosynthetic gene cluster. Analyses of generated mutants as well as feeding experiments allowed us to determine that LanGT2 and LanGT3 catalyze the attachment of one sugar, whereas LanGT1 and LanGT4 attach two sugars during landomycin...

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Source

Identifiers

PMID: 16039521
DOI: 10.1016/j.chembiol.2005.05.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Iteratively acting glycosyltransferases involved in the hexasaccharide biosynthesis of landomycin A.PMID 16039521Read ↗

Generation of new landomycins with altered saccharide patterns through over-expression of the glycosyltransferase gene lanGT3 in the biosynthetic gene cluster of landomycin A in Streptomyces cyanogenus S-136.Semantic proximity Read ↗

LanGT2 Catalyzes the First Glycosylation Step during landomycin A biosynthesis.Semantic proximity Read ↗

Function of lanGT3, a glycosyltransferase gene involved in landomycin A biosynthesis.Semantic proximity Read ↗

Elucidation of the function of two glycosyltransferase genes (lanGT1 and lanGT4) involved in landomycin biosynthesis and generation of new oligosaccharide antibiotics.Semantic proximity Read ↗

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