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<i>CDKN2A</i>, <i>CDKN2B</i> and <i>p14 <sup>ARF</sup></i> are frequently and differentially methylated in ependymal tumours

3 Nov 2003

Abstract excerpt

Ependymal tumours are histologically and clinically varied lesions. Numerical abnormalities of chromosome 9 are frequently associated with these tumours. Nevertheless, the three important tumour suppressor genes located in this chromosome, CDKN2A, CDKN2B and p14 ARF, have not been reported to be commonly altered in them. We studied promoter methylation of these genes, an important mechanism associated with gene...

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PMID: 14636164
DOI: 10.1046/j.0305-1846.2003.00505.x

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