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Article

AAV- based vector improvements unrelated to capsid protein modification

3 Feb 2023

Abstract excerpt

. To date, three AAV-based gene therapeutic agents have been approved by the FDA and are used in clinical practice. Despite the distinct advantages of gene therapy development, it is clear that AAV vectors need to be improved. Enhancements in viral vectors are mainly associated with capsid protein modifications. However, there are other structures that significantly affect the AAV life cycle and transduction. The...

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PMID: 36817775
DOI: 10.3389/fmed.2023.1106085

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