CYP2D6 genotype: impact on adverse effects and nonresponse during treatment with antidepressants-a pilot study.

doi:10.1016/j.clpt.2003.12.015

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Article

CYP2D6 genotype: impact on adverse effects and nonresponse during treatment with antidepressants-a pilot study.

Clinical pharmacology and therapeutics - 1 May 2004

Rau Thomas, Wohlleben Gerlinde, Wuttke Henrike, Thuerauf Norbert, Lunkenheimer Jens, Lanczik Mario, Eschenhagen Thomas

Abstract excerpt

OBJECTIVE: Treatment with antidepressants is frequently associated with adverse effects or insufficient clinical response. Several antidepressants are metabolized by cytochrome P450 (CYP) 2D6. The activity of this enzyme markedly varies among individuals from poor to ultrarapid metabolism on the basis of the polymorphism of the CYP2D6 gene. This association study investigated whether the CYP2D6 genotype...

Topics

Antidepressive Agents
Cytochrome P-450 CYP2D6
Depressive Disorder
Female
Genotype
Germany
Humans
Male
Middle Aged
Pilot Projects
Polymerase Chain Reaction
Polymorphism, Genetic
Retrospective Studies
Treatment Failure

Source

Open in PubMed

Identifiers

PMID: 15116051
DOI: 10.1016/j.clpt.2003.12.015

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