Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Platelet-activating factor-acetylhydrolase and PAF-receptor gene haplotypes in relation to future cardiovascular event in patients with coronary artery disease.

Human molecular genetics - 1 Jul 2004

Ninio Ewa, Tregouet David, Carrier Jean-Luc, Stengel Dominique, Bickel Christoph, Perret Claire, Rupprecht Hans J, Cambien François, Blankenberg Stefan, Tiret Laurence

Abstract excerpt

Oxidation of low density lipoproteins is an initial step of atherogenesis that generates pro-inflammatory phospholipids, including platelet-activating factor (PAF) and its analogs. PAF is degraded by PAF-acetylhydrolase (PAF-AH), a circulating enzyme having both pro- and anti-inflammatory activities. PAF-AH activity has been postulated to be a risk factor for coronary artery disease (CAD); however, whether PAF-AH...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 1-Alkyl-2-acetylglycerophosphocholine Esterase
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cohort Studies

Share to Coronary Artery Disease

Share to Haplotypes

Share to Lipoproteins, LDL

Share to Platelet Membrane Glycoproteins

Share to Receptors, G-Protein-Coupled

Source

Identifiers

PMID: 15115767
DOI: 10.1093/hmg/ddh145

Genes

CAD
PTAFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Platelet-activating factor-acetylhydrolase and PAF-receptor gene haplotypes in relation to future cardiovascular event in patients with coronary artery disease.PMID 15115767Read ↗

Lipoprotein-associated phospholipase A2 single-nucleotide polymorphisms and cardiovascular events in patients with coronary artery disease.Semantic proximity Read ↗

Association of platelet-activating factor acetylhydrolase gene polymorphism with premature coronary artery disease in Turkish patients.Semantic proximity Read ↗

PLA2G7 genotype, lipoprotein-associated phospholipase A2 activity, and coronary heart disease risk in 10 494 cases and 15 624 controls of European Ancestry.Semantic proximity Read ↗

Platelet-activating factor-acetylhydrolase A379V (exon 11) gene polymorphism is an independent and functional risk factor for premature myocardial infarction.Semantic proximity Read ↗

Comprehensive genetic analysis of the platelet activating factor acetylhydrolase (PLA2G7) gene and cardiovascular disease in case-control and family datasets.Semantic proximity Read ↗

Both paraoxonase-1 genotype and activity do not predict the risk of future coronary artery disease; the EPIC-Norfolk Prospective Population Study.Semantic proximity Read ↗

Association between lipoprotein-associated phospholipase A2 gene polymorphism and coronary artery disease in the Chinese Han population.Semantic proximity Read ↗

VDR Gene Polymorphisms in Healthy Individuals with Family History of Premature Coronary Artery Disease.Semantic proximity Read ↗

Platelet activating factor-acetylhydrolase (PAF-AH) activity and HDL levels, but not PAF-AH gene polymorphisms, are associated with successful aging in Sicilian octogenarians.Semantic proximity Read ↗

The Association of ADAMTS7 Gene Polymorphisms with the Risk of Coronary Artery Disease Occurrence and Cardiovascular Survival in the Polish Population: A Case-Control and a Prospective Cohort Study.Semantic proximity Read ↗

TAFI gene haplotypes, TAFI plasma levels and future risk of coronary heart disease: the PRIME Study.Semantic proximity Read ↗

Association between the Ala379Val variant of the lipoprotein associated phospholipase A2 and risk of myocardial infarction in the north and south of Europe.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.