Somatic mutations can lead to a loss of superantigenic and polyreactive binding.

Abstract excerpt

Although antibodies have been assumed to bind a specific antigen, evidence exists showing that a single antibody can bind to multiple unrelated antigens. We previously studied a human monoclonal antibody expressing a mutated form of the V(H)3-73 gene and displaying anti-tubulin activity in a patient suffering from an immunocytic lymphoma. Despite its expression of a V(H)3 family member, this immunoglobulin failed...

Topics

• Amino Acid Sequence
• Humans
• Immunoglobulin M
• Molecular Sequence Data
• Mutation
• Protein Binding
• Protein Structure, Tertiary
• Superantigens
• Temperature
• Tubulin