Article
Tumour cell binding by a human monoclonal IgM antibody from the spleen of a non-tumour-associated patient is due to somatic mutations in the VH gene.
Clinical and experimental immunology - 1 Mar 1995
Bohn J, Niemann B, Roggenbuck D, Döcke W, Jahn S
Abstract excerpt
Recently we described the occurrence of B cells producing polyspecific natural IgM with anti-tumour specificity in the spleen of non-tumour-bearing individuals as well as in fetal organisms. Immunoprecipitation and 2-D electrophoresis showed the binding of such antibodies to a 55-kD (pI 6.0) memb...
Topics
- Amino Acid Sequence
- Antibodies, Monoclonal
- Antibodies, Neoplasm
- Base Sequence
- Humans
- Hybridomas
- Immunoglobulin Heavy Chains
- Immunoglobulin M
- Immunoglobulin Variable Region
- Molecular Sequence Data
- Mutation
- Spleen
- Tumor Cells, Cultured