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Article

Enhancement of pathogenicity of Newcastle disease virus by alteration of specific amino acid residues in the surface glycoproteins F and HN.

Avian diseases - 1 Jun 2006

Römer-Oberdörfer Angela, Veits Jutta, Werner Ortrud, Mettenleiter Thomas C

Abstract excerpt

Recombinant viruses were rescued after site-specific mutagenesis of a full-length clone of the lentogenic Newcastle disease virus (NDV) strain Clone 30. To assess the contribution of different amino acids to virulence, specific alterations were introduced into the fusion (F) protein and in the hemagglutinin-neuraminidase (HN) protein based on sequence comparison between NDV strains of different virulence....

Topics

Amino Acid Substitution
Animals
Cell Line
Chick Embryo
DNA, Complementary
Mutagenesis, Site-Directed
Mutation
Newcastle disease virus
Quail
Viral Envelope Proteins
Virulence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Virus Replication

Source

Identifiers

PMID: 16863077
DOI: 10.1637/7471-111505R.1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-16863077-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Enhancement of pathogenicity of Newcastle disease virus by alteration of specific amino acid residues in the surface glycoproteins F and HN.PMID 16863077Read ↗

Contribution of the length of the HN protein and the sequence of the F protein cleavage site to Newcastle disease virus pathogenicitySemantic proximity Read ↗

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Screening and mechanistic study of key sites of the hemagglutinin-neuraminidase protein related to the virulence of Newcastle disease virusSemantic proximity Read ↗

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Virulence of newcastle disease virus: what is known so far?Semantic proximity Read ↗

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