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Article

The hemagglutinin-neuraminidase protein of Newcastle disease virus determines tropism and virulence.

Journal of virology - 1 Apr 2004

Huang Zhuhui, Panda Aruna, Elankumaran Subbiah, Govindarajan Dhanasekaran, Rockemann Daniel D, Samal Siba K

Abstract excerpt

The hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) plays a crucial role in the process of infection. However, the exact contribution of the HN gene to NDV pathogenesis is not known. In this study, the role of the HN gene in NDV virulence was examined. By use of reverse genetics procedures, the HN genes of a virulent recombinant NDV strain, rBeaudette C (rBC), and an avirulent...

Topics

Animals
Base Sequence
Cell Line
Chick Embryo
Chimera
Chlorocebus aethiops
Cytopathogenic Effect, Viral
DNA, Viral
Genes, Viral
HN Protein
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Newcastle Disease

Newcastle disease virus

Vero Cells

Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 15047833
DOI: 10.1128/jvi.78.8.4176-4184.2004
PMCID: PMC374304

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15047833-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The hemagglutinin-neuraminidase protein of Newcastle disease virus determines tropism and virulence.PMID 15047833Read ↗

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