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Article

Dioxin-induced Immortalization of Normal Human Keratinocytes and Silencing of p53 and p16INK4a

1 Jun 2004

Abstract excerpt

Dioxin, a potent tumor promoter, activates the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor belonging to the basic helix-loop-helix-PAS family, to enhance tumorigenesis via unknown mechanisms. We undertook this study to determine the mechanisms underlying the impact of dioxin on cell fate, in particular senescence that occurs in normal human cells and is considered to play important...

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PMID: 15111621
DOI: 10.1074/jbc.m402771200

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