Article
Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity.
Journal of medical genetics - 1 May 2005
Andersen G, Wegner L, Yanagisawa K, Rose C S, Lin J, Glümer C, Drivsholm T, Borch-Johnsen K, Jørgensen T, Hansen T, Spiegelman B M, Pedersen O
Abstract excerpt
BACKGROUND: Peroxisome proliferator activated receptor-gamma coactivator-1beta (PGC-1beta) is a recently identified homologue of the tissue specific coactivator PGC-1alpha, a coactivator of transcription factors such as the peroxisome proliferators activated receptors and nuclear respiratory factors. PGC-1alpha is involved in adipogenesis, mitochondrial biogenesis, fatty acid beta oxidation, and hepatic...
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