Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comparison of gene expression in HCT116 treatment derivatives generated by two different 5-fluorouracil exposure protocols.

Molecular cancer - 26 Apr 2004

De Angelis Paula M, Kravik Katherine L, Tunheim Siv H, Haug Terje, Reichelt Wenche H

Abstract excerpt

BACKGROUND: Established colorectal cancer cell lines subjected to different 5-fluorouracil (5-FU) treatment protocols are often used as in vitro model systems for investigations of downstream cellular responses to 5-FU and to generate 5-FU-resistant derivatives for the investigation of biological mechanisms involved in drug resistance. We subjected HCT116 colon cancer cells to two different 5-FU treatment...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Cluster Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colonic Neoplasms

Share to Dose-Response Relationship, Drug

Share to Drug Resistance, Neoplasm

Share to Fluorouracil

Share to Oligonucleotide Array Sequence Analysis

Share to RNA, Neoplasm

Source

Open in PubMed Open full text

Identifiers

PMID: 15109396
DOI: 10.1186/1476-4598-3-11
PMCID: PMC411052

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Comparison of gene expression in HCT116 treatment derivatives generated by two different 5-fluorouracil exposure protocols.PMID 15109396Read ↗

Dissecting progressive stages of 5-fluorouracil resistance in vitro using RNA expression profiling.Semantic proximity Read ↗

Colon Cancer Cells Gene Expression Signature As Response to 5- Fluorouracil, Oxaliplatin, and Folinic Acid TreatmentSemantic proximity Read ↗

APRIL is a novel clinical chemo-resistance biomarker in colorectal adenocarcinoma identified by gene expression profilingSemantic proximity Read ↗

Epigenomics alternations and dynamic transcriptional changes in responses to 5-fluorouracil stimulation reveal mechanisms of acquired drug resistance of colorectal cancer cellsSemantic proximity Read ↗

Deciphering cellular states of innate tumor drug responsesSemantic proximity Read ↗

Gene expression profiling of 49 human tumor xenografts from in vitro culture through multiple in vivo passages - strategies for data mining in support of therapeutic studiesSemantic proximity Read ↗

Apoptosis, cell cycle progression and gene expression in TP53-depleted HCT116 colon cancer cells in response to short-term 5-fluorouracil treatmentSemantic proximity Read ↗

Stable differentiation of a human colon adenocarcinoma cell line by sodium butyrate is associated with multidrug resistance.Semantic proximity Read ↗

Chronic exposure of VEGF inhibitors promotes the malignant phenotype of colorectal cancer cells.Semantic proximity Read ↗

Decreased levels of UMP kinase as a mechanism of fluoropyrimidine resistanceSemantic proximity Read ↗

Anticancer drug response and expression of molecular markers in early-passage xenotransplanted colon carcinomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.