Article
Anticancer drug response and expression of molecular markers in early-passage xenotransplanted colon carcinomas.
European journal of cancer (Oxford, England : 1990) - 1 Jan 2004
Fichtner I, Slisow W, Gill J, Becker M, Elbe B, Hillebrand T, Bibby M
Abstract excerpt
Despite some success in the treatment of colorectal carcinomas, novel rational therapies targeting specific cancer-related molecules are under development and urgently needed. These approaches need careful preclinical evaluation in models that closely mirror the clinical situation. Therefore, we established a panel of 15 xenotransplantable tumours directly from fresh surgical material. We showed that both the...
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