Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Decreased levels of UMP kinase as a mechanism of fluoropyrimidine resistance

21 Apr 2009

Abstract excerpt

5-Fluorouracil (5-FU) continues to be widely used for treatment of gastrointestinal cancers. Because many tumors show primary or acquired resistance, it is important to understand the molecular basis underlying the mechanism of resistance to 5-FU. In addition to its effect on thymidylate synthase inhibition and DNA synthesis, 5-FU may also influence RNA metabolism. Our previous studies revealed that colorectal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholangiocarcinoma and Gallbladder Cancer Studies
Share to Colorectal Cancer Treatments and Studies
Share to Gastric Cancer Management and Outcomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19383847
DOI: 10.1158/1535-7163.mct-08-0716

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Decreased levels of UMP kinase as a mechanism of fluoropyrimidine resistancePMID 19383847Read ↗

Review of 5-FU resistance mechanisms in colorectal cancer: clinical significance of attenuated on-target effectsSemantic proximity Read ↗

Molecular Mechanisms and Tumor Biological Aspects of 5-Fluorouracil Resistance in HCT116 Human Colorectal Cancer CellsSemantic proximity Read ↗

Reduced Activity of Anabolizing Enzymes in 5‐Fluorouracil‐resistant Human Stomach Cancer CellsSemantic proximity Read ↗

Novel mRNA isoforms and mutations of uridine monophosphate synthetase and 5-fluorouracil resistance in colorectal cancer.Semantic proximity Read ↗

Correlation between chemosensitivity and mRNA expression level of 5-fluorouracil-related metabolic enzymes during liver metastasis of colorectal cancerSemantic proximity Read ↗

Recent Updates on Mechanisms of Resistance to 5-Fluorouracil and Reversal Strategies in Colon Cancer TreatmentSemantic proximity Read ↗

Different mechanisms of acquired resistance to fluorinated pyrimidines in human colorectal cancer cells.Semantic proximity Read ↗

Thymidylate synthase (TS) and ribonucleotide reductase (RNR) may be involved in acquired resistance to 5-fluorouracil (5-FU) in human cancer xenografts in vivoSemantic proximity Read ↗

UBE2S promotes 5-fluorouracil resistance in colorectal cancer by activating non-canonical NF-κB/TYMS/TK1 signalingSemantic proximity Read ↗

DNA mismatch repair (MMR)‐dependent 5‐fluorouracil cytotoxicity and the potential for new therapeutic targetsSemantic proximity Read ↗

Mechanistic and predictive profiling of 5-Fluorouracil resistance in human cancer cells.Semantic proximity Read ↗

Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.