Article
Contribution of the hormone-response elements of the proximal ApoA-I promoter, ApoCIII enhancer, and C/EBP binding site of the proximal ApoA-I promoter to the hepatic and intestinal expression of the ApoA-I and ApoCIII genes in transgenic mice.
Biochemistry - 4 May 2004
Kan Horng-Yuan, Georgopoulos Spiros, Zanni Markella, Shkodrani Adelina, Tzatsos Alexandros, Xie Hou Xiang, Zannis Vassilis I
Abstract excerpt
We have generated and studied the pattern of expression of transgenic mouse lines carrying the human apoA-I and apoCIII gene cluster mutated at different sites. In two lines, we have either mutated the hormone-response element (HRE) of element G of the apoCIII enhancer or the C/EBP binding site of the proximal apoA-I promoter. In a third line, we have mutated the two HREs of the apoA-I promoter and the HRE of the...
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