Article
Intestinal apolipoprotein A-IV gene transcription is controlled by two hormone-responsive elements: a role for hepatic nuclear factor-4 isoforms.
Molecular endocrinology (Baltimore, Md.) - 1 Sept 2005
Archer Amena, Sauvaget Dominique, Chauffeton Valérie, Bouchet Pierre-Etienne, Chambaz Jean, Pinçon-Raymond Martine, Cardot Philippe, Ribeiro Agnès, Lacasa Michel
Abstract excerpt
In the small intestine, the expression of the apolipoprotein (apo) C-III and A-IV genes is restricted to the enterocytes of the villi. We have previously shown that, in transgenic mice, specific expression of the human apo C-III requires a hormone-responsive element (HRE) located in the distal region of the human apoA-IV promoter. This HRE binds the hepatic nuclear factors (HNF)-4alpha and gamma. Here,...
Topics
- Animals
- Apolipoproteins A
- Caco-2 Cells
- Enhancer Elements, Genetic
- Enterocytes
- Gene Expression Regulation
- Humans
- Intestine, Small
- Mice
- Mice, Transgenic