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Article

Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C.

The EMBO journal - 1 Apr 1990

Jakobovits A, Rosenthal A, Capon D J

Abstract excerpt

Human immunodeficiency virus (HIV) spends a significant part of the viral life cycle as a latent provirus integrated into the host genome. Activation of latent HIV-1 requires mitogenic stimulation of the cell, which increases basal viral transcription, and the HIV-1 tat protein. As tat itself dramatically increases HIV-1 gene expression, it too is presumably regulated in the latent state, and may also be...

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Identifiers

PMID: 2182321
DOI: 10.1002/j.1460-2075.1990.tb08223.x
PMCID: PMC551792

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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