Article
Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C.
The EMBO journal - 1 Apr 1990
Jakobovits A, Rosenthal A, Capon D J
Abstract excerpt
Human immunodeficiency virus (HIV) spends a significant part of the viral life cycle as a latent provirus integrated into the host genome. Activation of latent HIV-1 requires mitogenic stimulation of the cell, which increases basal viral transcription, and the HIV-1 tat protein. As tat itself dramatically increases HIV-1 gene expression, it too is presumably regulated in the latent state, and may also be...
Topics
- Cell Line
- Gene Expression Regulation, Viral
- Gene Products, tat
- Genes, Viral
- HIV-1
- Humans
- Mutation
- Phorbol 12,13-Dibutyrate
- Plasmids
- Promoter Regions, Genetic
- Protein Kinase C
- Repetitive Sequences, Nucleic Acid