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Article

P53 down-regulates matrix metalloproteinase-1 by targeting the communications between AP-1 and the basal transcription complex.

Journal of cellular biochemistry - 15 May 2004

Sun Yubo, Zeng Xiao-Rong, Wenger Leonor, Firestein Gary S, Cheung Herman S

Abstract excerpt

We have previously reported that human matrix metalloproteinase-1 (MMP1) is a p53 target gene subject to down-regulation (Sun et al. [1999]: J Biol Chem 274:11535-11540]. In the present study, we demonstrate that the down-regulation of the human -83MMP1 promoter fragment by p53 was abolished when the -72AP-1 site was eliminated and that a GAL4-cJun-mediated but not a GAL4-Elk1-mediated induction of pFR-luci was...

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Source

Identifiers

PMID: 15108353
DOI: 10.1002/jcb.20044

Genes

MMP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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